Podcast #98: Amiodarone and Lidocaine in Out-of-Hospital Cardiac Arrest

066c2ece-7413-42fb-bdae-9f00347a151dRun Time: 4 minutes

Author:  Dr. Jared Scott

Educational Pearls:

  • A recent study in the NEJM looked at the efficacy of lidocaine and amiodarone for use in out-of-hospital cardiac arrest.
  • About 1/3 of the 3000 participants in the trial were randomized to a placebo, 1/3 to amiodarone, and 1/3 to lidocaine. The primary outcomes used were survival to hospital discharge and good neurological function at discharge to indicate a favorable outcome.
  • With amiodarone 24% of the patients had a favorable outcome, with lidocaine 24% of the patients had a favorable outcome, and with a placebo 21% of the patients had a favorable outcome. These findings bear no statistical significance to indicate benefits of using these drugs during out-of-hospital cardiac arrest.
  • Jared’s take away – quick access to electricity and good, deep, uninterrupted CPR should not be sacrificed to push medications for patients in cardiac arrest.

Link to Podcast:  http://medicalminute.madewithopinion.com/amioderone-and-lidocaine-in-out-of-hospital-cardia/

References:  http://www.nejm.org/doi/full/10.1056/NEJMoa1514204

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