Run Time: 2 minutes
Author: Dr. Nicholas Hatch
- Angioedema is usually caused by an allergic reaction and can be induced by ACE inhibitors as well as tissue plasminogen activator (TPA).
- Angioedema is caused by the build up of bradykinins resulting in the leaking of capillaries and swelling of tissue.
- TPA-induced angioedema is reported to occur in 1.6% of the patients who receive TPA and is more severe than ACE inhibitor-induced angioedema.
- Giving solu-medrol to treat ACE inhibitor-induced angioedema is the standard of care, although its actual benefit is limited.
- FFP and icatibant (which is a bradykinin receptor antagonist) have been shown to provide more benefit in treatment of angioedema. These are much more expensive options than solu-medrol, with the 30 mg of SubQ icatibant costing the hospital $5000 dollars per dose.
- ACE inhibitor-induced angioedema lasts on average 27 hours before the symptoms subside.
Link to Podcast: http://medicalminute.madewithopinion.com/angioedema/