Contributor: Aaron Lessen, MD
- Ivermectin is an antiparasitic medication that has been used for a long time, but has sparked new interest in the past year as a potential treatment for COVID-19
- In-vitro studies have shown it decreases how quickly COVID replicates and may make it less likely to adhere to cells
- Observational studies have found lower rates of COVID-19 infections in areas that provide ivermectin prophylaxis
- In several studies it was shown that it decreased severity and mortality, though there were significant methodological limitations
- NIH gave a statement saying there is not enough evidence to support or refute based on current trials and larger more rigorous trials are needed
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Hellwig MD, Maia A. A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of ivermectin. Int J Antimicrob Agents. 2021 Jan;57(1):106248. doi: 10.1016/j.ijantimicag.2020.106248. Epub 2020 Nov 28. PMID: 33259913; PMCID: PMC7698683.
Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter JJ. Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019: The Ivermectin in COVID Nineteen Study. Chest. 2021 Jan;159(1):85-92. doi: 10.1016/j.chest.2020.10.009. Epub 2020 Oct 13. PMID: 33065103; PMCID: PMC7550891.
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Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD