Contributor: Don Stader, MD
- The common causes of anion gap metabolic acidosis include (MUDPILES)
- Metformin, Methanol
- Ethylene Glycol
- Metformin is a very common drug used to treat type 2 diabetes, however in the right setting, it can cause a profound lactic acidosis. There is a very high mortality rate.
- Treatment of metformin toxicity includes fluids, bicarb, and dialysis
- Most commonly, metformin toxicity is in the setting of kidney injury or overdose.
- Always consider acidosis in those with tachypnea!
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Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD