Podcast #42: Andexanet for Xarelto?!

Run Time: 2 minutes

1069711_factor-xa-molecular-structure-15Author: Rachael Duncan, PharmD BCPS

Educational Pearls:

  • Eliquis and Xarelto are oral anticoagulants that inhibit the clotting cascade.
  • Currently prothrombin complex concentrate or PCC can be used to reverse the effects of Xarelto or Eliquis by overpowering the inhibition of the clotting cascade.
  • Andexanet is a medication currently in phase III trials that is purposed with sequestering the anticoagulant effects of Xarelto and Eliquis, instead of simply overpowering the inhibition of the clotting cascade as PCC does.

Link to Podcast: http://medicalminute.madewithopinion.com/adexanet-for-xeralto/

References: http://www.nejm.org/doi/full/10.1056/NEJMoa1510991


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