Run Time: 3 minute
Author: Dr. Samuel Killian
- 5 million people are on Coumadin. Coumadin is in the top 5 of most adverse events.
- 2 options for reversal in the ER: Vitamin K and FFP or vitamin K and 4 factor PCC.
- FFP is cheap but harder to use and takes longer – 18-20 hours. Also there are several complications such as: AVO compatibility, volume of medication, and transfusion injuries.
- PCC is expensive, easier to use, and takes less time – 15 minutes. PCC has less adverse effects and reactions.
- Study showed that 14 patients given FFP had complications (7%), and 14 patients given PCC had complications – mortality rate was the same.
- PCC has rapidly become preferred method for reversing Coumadin coagulopathy for sick patients – head bleeds, gi bleeding, etc.