Author: Jared Scott, M.D.
- Recent study compared Compazine with Benadryl vs. Dilaudid for acute migraine management in the ED.
- Compazine + Benadryl demonstrated migraine relief in 60% of patients compared to the 31% of patients who were relieved with Dilaudid.
- Compazine + Benadryl is a superior migraine treatment than Dilaudid.
Friedman BW, et. al. (2017). Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine. Neurology. 89(20):2075-2082