Podcast #24: Stevens-Johnson Sydrome/ TENS

a1f73a72-7248-488a-a23f-1fe7baba50cbRun Time: 7 minutes

Author: Dr. Donald Stader

Educational Pearls:

  • Stevens-Johnson Syndrome (SJS) was first described in 1922 by pediatricians Dr. Stevens and Dr. Johnson after severe rash and skin peeling in one of their patients.
  • SJS is described on a scale of <10% of body affected is Steve-Johnson Syndrome, 10%-30% is called Steven-Johnson/TENS, and >30% is called TENS (Toxic Epidermal Necrolysis).
  • The CD48 T-cells and natural killer cells attack the skin at the dermal-epidermal junction after drug trigger or infectious trigger – the body thinks its own cells are toxic.
  • Patients are affected with mainly mouth and eye symptoms before a rash erupts that progress from red to blistering to sloughing.
  • Patients are cared for like burn patients, but in the ER do not need as much fluid as burn patients.
  • The majority of mortality is due to either Psuedomonas or Staph infections.

Link to Podcast:  http://medicalminute.madewithopinion.com/stevens-johnson-syndrome-tens/

References:  http://www.dermnetnz.org/reactions/sjs-ten.html

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