Run Time: 7 minutes

Author: Dr. Donald Stader

Educational Pearls:

• Stevens-Johnson Syndrome (SJS) was first described in 1922 by pediatricians Dr. Stevens and Dr. Johnson after severe rash and skin peeling in one of their patients.
• SJS is described on a scale of <10% of body affected is Steve-Johnson Syndrome, 10%-30% is called Steven-Johnson/TENS, and >30% is called TENS (Toxic Epidermal Necrolysis).
• The CD48 T-cells and natural killer cells attack the skin at the dermal-epidermal junction after drug trigger or infectious trigger – the body thinks its own cells are toxic.
• Patients are affected with mainly mouth and eye symptoms before a rash erupts that progress from red to blistering to sloughing.
• Patients are cared for like burn patients, but in the ER do not need as much fluid as burn patients.
• The majority of mortality is due to either Psuedomonas or Staph infections.

Link to Podcast:  http://medicalminute.madewithopinion.com/stevens-johnson-syndrome-tens/

References:  http://www.dermnetnz.org/reactions/sjs-ten.html