Podcast #223: Acyclovir Toxicity

Author: Nick Hatch, M.D.

Educational Pearls

  • Acyclovir toxicity can uncommonly cause altered mental status, low blood glucose, hallucinations and myoclonic jerks.
  • Toxicity often occurs in the setting of renal insufficiency, as it is cleared by the kidneys.
  • Acyclovir is often used to treat shingles, which can also cause similar symptoms as acyclovir toxicity due to encephalitis – rule this out in the setting of a concomitant shingles infection.

References: http://www.rxlist.com/zovirax-drug.htm

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