Podcast #165: TTP

fafc49c3-5bf2-4289-bf57-a58c8cfd5ac6Run Time: 5 minutes

Author: Eric Miller M.D.

Educational Pearls:

  • TTP stands for thrombotic thrombocytopenic purpura.
  • TTP patients usually have renal failure, bruising or petechia, anemia, confusion, and other neurologic changes, which distinguishes itself from ITP which is mostly characterized by just low platelets and petechia.
  • Both TTP and ITP are thought to be autoimmune diseases where the body produces antibodies that attack your own platelets or blood clotting mechanisms, preventing blood from clotting. In the case of TTP – antibodies attack a protein called ADAM TS-13, which cleaves Von Willibrand Factor.
  • Without treatment TTP has a 95% mortality rate, but with treatment patients have a 5-10% mortality rate.
  • Patients with TTP are admitted to the ICU and receive complete plasma transfusions daily – which takes out the antibodies that prevent clotting, dialysis for kidney failure, and steroids – because the majority of autoimmune diseases respond to steroids.
  • Causes of TTP can be infectious, chemotherapy, or common medications. However, only about 4 out of 1 million people get TTP yearly.
  • Pediatric patients who have hemolytic uremic syndrome have similar symptoms, and usually have a bacterial gastorintestinal infection from E.coli or Shigella toxin.

Link to Podcast: http://medicalminute.madewithopinion.com/ttp/

References: https://www.nhlbi.nih.gov/health/health-topics/topics/ttp

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