Run Time: 3 minutes
Author: Rachael Duncan, PharmD BCPS
- Inotropes are used for cardiogenic shock patients, specifically when volume status is elevated and the cardiac output is low.
- Dobutamine acts on beta-1 and beta-2 adrenergic receptors, increasing contractility and blood pressure. It also causes vasodilation – for patients with a systolic blood pressure less than 80 caution is advised. It could be beneficial to have levophed hanging in the case of a hypotensive episode.
- Milrinone is a phosphodiesterase-3 inhibitor that blocks breakdown of cyclic AMP.
- Dobutamine has a half life of minutes, whereas milrinone has a half life of hours.
Link to Podcast: http://medicalminute.madewithopinion.com/inotropes/