Podcast #102: Inotropes

06e33b8d-333e-4a2d-a0a3-3da1b3ff3468Run Time: 3 minutes

Author: Rachael Duncan, PharmD BCPS

Educational Pearls:

  •       Inotropes are used for cardiogenic shock patients, specifically when volume status is elevated and the cardiac output is low.
  •       Dobutamine acts on beta-1 and beta-2 adrenergic receptors, increasing contractility and blood pressure. It also causes vasodilation – for patients with a systolic blood pressure less than 80 caution is advised. It could be beneficial to have levophed hanging in the case of a hypotensive episode.
  •       Milrinone is a phosphodiesterase-3 inhibitor that blocks breakdown of cyclic AMP.
  •       Dobutamine has a half life of minutes, whereas milrinone has a half life of hours.

Link to Podcast: http://medicalminute.madewithopinion.com/inotropes/

References:  http://circ.ahajournals.org/content/118/10/1047.full

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