Podcast # 479: Clots and Pregnancy

Author:  Nick Hatch, MD

Educational Pearls:

  • Pregnancy is a hypercoagulable state, which predisposes women to venous thromboembolism, but also elevates levels of circulating d-dimer
  • A recent study evaluated the YEARS protocol in combination of adjusted d-dimer cutoffs in pregnant women to evaluate for DVT and PE
  • Using this protocol, only 1 DVT was missed. No PE’s were missed.
  • This protocol has growing evidence as an option in pregnant women in whom you must rule out a DVT/PE but more validating studies are likely necessary


van der Pol LM, Tromeur C, Bistervels IM, Ni Ainle F, van Bemmel T, Bertoletti L, Couturaud F, van Dooren YPA, Elias A, Faber LM, Hofstee HMA, van der Hulle T, Kruip MJHA, Maignan M, Mairuhu ATA, Middeldorp S, Nijkeuter M, Roy PM, Sanchez O, Schmidt J, Ten Wolde M, Klok FA, Huisman MV. Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism. N Engl J Med. 2019 Mar 21;380(12):1139-1149. doi: 10.1056/NEJMoa1813865. PubMed PMID: 30893534.

Summarized by Will Dewispelaere, MS3 | Edited by Erik Verzemnieks, MD


Check out this episode!

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Podcast #101: The Top Ten

Here is our long-awaited top ten of the first 100 podcasts. Enjoy them all here: http://medicalminute.madewithopinion.com/the-top-10/

For our acutely interested viewers, you can find each individual podcast in the top ten listed here:

#10: Alexis St. Martin by Dr. Christopher Holmes

#9: Difficult IV Access by Dr. Dylan Luyten

#8: Isopropyl Alcohol for Nausea by Dr. Donald Stader

#7: Baby Botulism by Dr. Erik Verzemnieks

#6: Ketamine! by Dr. Michael Hunt

#5: Paroxysmal Atrial Fibrillation by Dr. Peter Bakes

#4: 420! A Marijuana Podcast by Dr. Donald Stader

#3: Snake Bites by Dr. Gregory Burcham

#2: Burn Victims and Cyanokit by Rachel Duncan PharmD

  • http://medicalminute.madewithopinion.com/burn-victims-and-cyanokit/

#1: Diphtheria and March the 18th by Dr. David Rosenberg


Comments? Have an idea for a new medical minute?  Contact Us @ emergencymedicalminute@gmail.com

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~ William Osler


Cure sometimes, treat often, comfort always.

~ Hippocrates